To our knowledge, this is the first study to implement a comprehensive risk-based mammography screening programme in Asia. For national implementation of personalised risk-based breast screening, exploration of the acceptability within the target populace is critical, in addition to validated predication tools. Risk prediction is based on: a) Gail model (non-genetic), b) mammographic density and recall, c) BOADICEA predictions (breast cancer predisposition genes), and d) breast cancer polygenic risk score. After receiving a tailored breast cancer risk report, participants will attend an in-person risk review, followed by a final session assessing the acceptability of our risk stratification programme. The first recruitment visit will include questionnaires and a buccal cheek swab.
BREATHE is a cohort study targeting to recruit ~3,500 women. Advancing beyond the current age-based screening paradigm, BREATHE integrates both genetic and non-genetic breast cancer risk prediction tools to personalise screening recommendations. The BREAst screening Tailored for HEr (BREATHE) study aims to assess acceptability of a comprehensive risk-based personalised breast screening in Singapore. However, breast cancer risk varies by individual. Current breast screening programmes are one-size-fits-all which all women above a certain age threshold are encouraged to participate. Routine mammography screening is currently the standard tool for finding cancers at an early stage, when treatment is most successful.
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